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One or more keywords matched the following properties of Vadgama, Jaydutt
PropertyValue
keywords Cancer Research
keywords Community Based translational research
overview Dr. Vadgama is the Vice President for Research and Health Affairs at Charles R. Drew University of Medicine and Science (CDU). He is a full Professor of Medicine at CDU and at the UCLA David Geffen School of Medicine in the Department(s) of Internal Medicine. Dr. Vadgama has provided significant leadership in growing and sustaining research at CDU over the last two decades. Dr. Vadgama has led several additional administrative responsibilities that include Chair of the Institutional Space Committee, Chair of the PhD Planning Committee, establishing the Intellectual Property/Patent Committee at CDU, Institutional Official for IACUC and chairing several Task Force committees. Leadership Experience: Dr. Vadgama continues to serve as Division Chief, Center Director, Vice President, member of the President’s Executive Team and the Provost’s Team in addition to several additional executive roles. He has over 30 years of direct experience in Academia and Research with a strong understanding of the processes, policies and procedures necessary to attain academic excellence. He continues to provide significant support and leadership to students, faculty, the Academic Senate, division chiefs, department chairs, deans, provosts and the University president on matters relevant to research, academic processes, challenges and growth. He continues to work with faculty, students and staff to strengthen clinical, basic and translational research/programs, integrate them with academic programs across campus, and develop strong partnerships with UCLA, Cedars and other institutions. At the request of the University president and deans, he has represented the University at several national forums on cancer and health disparities and he serves in an advisory capacity to the president and the Executive Team for directing research initiatives at CDU in partnership with other institutions. Strength in Diversity: Dr. Vadgama has over 20 years of experience in working at Historically Black College and University (HBCU) and Hispanic Serving institution (HSI). In 1992/3, he joined Charles R. Drew University of Medicine and Science as Director of Laboratory Research and Development to develop research infrastructure in Biomedical Sciences that supported underrepresented and underserved undergraduate students, graduate students, medical residents, clinical fellows, postdoctoral fellows, and faculty. In addition, during these last 21 years and prior, he has had extensive experience working with underrepresented and under resourced communities in South Los Angeles and neighboring communities. Dr. Vadgama states: “It continues to be an honor and privilege to be able to make differences in the day to day lives of our students, faculty, staff, and community partners.” Translational Cancer Research Experience: Dr. Vadgama has extensive experience in conducting oncology research that integrates clinical, basic and community-partnered research. The outcome of these efforts has resulted in the development of translational cancer research at CDU. His research team is providing significant leadership in understanding the role of comorbidities such Diabetes and Hypertension in the risk and prognosis for cancer diagnosis and treatment. His group has identified that Obesity contributes significantly to the risk for cancer development and poor clinical outcome. The CDU/UCLA Cancer Center Partnership was recently refunded for over $12.6M (2015-2020) by the National Cancer Institute (U54CA143931) to enhance cancer disparities research at CDU and support programs in developing novel research, sustaining a biomarker identification repository, formal training programs for students, fellows, and faculty, as well as community engagement activities, and clinical research studies. In addition, Dr. Vadgama serves as PI for the Accelerating Excellence in Translational Science Center (U54MD007598), recently funded for $18.76M (2019-2025). The overall purpose of AXIS is to better position CDU for conducting clinical and translational research, especially research focused on health disparities. Other Professional Experience: Dr. Vadgama serves as reviewer for grants submitted to the NIH, DOD, VHA, and EPSRC. He is Editor-In-Chief of IJBS, Clinics in Oncology Journal and serves on the editorial board of 14 journals and an ad-hoc reviewer for 30 peer-reviewed journals. Dr. Vadgama has participated at national and international cancer meetings as chair, co-chair, invited honorary and keynote speaker. In addition, he has served on several community-partnered panels and conferences and honored with a Distinguished Achievement Award for Research and Community Partnership award from the Watts Area Ministers (WAM). Teaching and Training Experience: Dr. Vadgama has extensive experience in training students, residents and fellows in basic, clinical and translational cancer research. His training programs have been funded from the NIH since 2004 and he serves as mentor and reviewer for several training programs including the CTSI and Susan G. Komen Foundation. To date, Dr. Vadgama has mentored 59 postdoctoral and clinical fellows, 34 graduate students, 16 medical students (mostly underrepresented), 149 undergraduate students across the nation, and 35 high school students. Dr. Vadgama continues to serve as a mentor for several funded early stage investigators at CDU and the UCLA School of Medicine. In addition, he mentors several underrepresented trainees from schools such as CDU, UCLA, UCI, UCR, CSUDH, USC and others.
One or more keywords matched the following items that are connected to Vadgama, Jaydutt
Item TypeName
Academic Article The Research Centers in Minority Institutions (RCMI) Translational Research Network: Building and Sustaining Capacity for Multi-Site Basic Biomedical, Clinical and Behavioral Research.
Concept Brain Neoplasms
Concept Breast Neoplasms
Concept Uterine Cervical Neoplasms
Concept Lung Neoplasms
Concept Mammary Neoplasms, Experimental
Concept Neoplasms
Concept Prostatic Neoplasms
Concept Research Personnel
Concept Research Support as Topic
Concept Colorectal Neoplasms
Concept Mammary Neoplasms, Animal
Concept Behavioral Research
Concept Biomedical Research
Concept Early Detection of Cancer
Concept Community-Based Participatory Research
Grant CDU-UCLA Cancer Center Partnership to Eliminate Cancer Health Disparities
Grant Charles R. Drew Student Scholar Program
Grant Drew/UCLA Cancer Partnership Program
Academic Article Caspase 8 and maspin are downregulated in breast cancer cells due to CpG site promoter methylation.
Academic Article Connective tissue growth factor associated with oncogenic activities and drug resistance in glioblastoma multiforme.
Academic Article Obesity is associated with breast cancer in African-American women but not Hispanic women in South Los Angeles.
Academic Article Expression of connective tissue growth factor (CTGF/CCN2) in breast cancer cells is associated with increased migration and angiogenesis.
Academic Article IGF gene polymorphisms and breast cancer in African-American and Hispanic women.
Academic Article Expression of FOXO1 is associated with GATA3 and Annexin-1 and predicts disease-free survival in breast cancer.
Academic Article Expression of Wnt3 activates Wnt/?-catenin pathway and promotes EMT-like phenotype in trastuzumab-resistant HER2-overexpressing breast cancer cells.
Academic Article Correlates of perceived risk of developing cancer among African-Americans in South Los Angeles.
Academic Article The clinical utilization of circulating cell free DNA (CCFDNA) in blood of cancer patients.
Academic Article Vitamin D receptor FokI gene polymorphisms may be associated with colorectal cancer among African American and Hispanic participants.
Academic Article IGF-1 regulates Cyr61 induced breast cancer cell proliferation and invasion.
Academic Article Epigenetics in breast and prostate cancer.
Academic Article Curcumin and epigallocatechin gallate inhibit the cancer stem cell phenotype via down-regulation of STAT3-NF?B signaling.
Academic Article Biologic roles of estrogen receptor-? and insulin-like growth factor-2 in triple-negative breast cancer.
Academic Article Combined inhibition of glycolysis and AMPK induces synergistic breast cancer cell killing.
Academic Article Identification of Novel Biomarkers for Metastatic Colorectal Cancer Using Angiogenesis-Antibody Array and Intracellular Signaling Array.
Academic Article FOXO1A is a target for HER2-overexpressing breast tumors.
Academic Article Triple negative breast tumors in African-American and Hispanic/Latina women are high in CD44+, low in CD24+, and have loss of PTEN.
Academic Article STAT3 activation in HER2-overexpressing breast cancer promotes epithelial-mesenchymal transition and cancer stem cell traits.
Academic Article Enhanced inhibition of prostate cancer xenograft tumor growth by combining quercetin and green tea.
Academic Article Constitutive activation of STAT3 signaling regulates hTERT and promotes stem cell-like traits in human breast cancer cells.
Academic Article Comparing perceived and test-based knowledge of cancer risk and prevention among Hispanic and African Americans: an example of community participatory research.
Academic Article Genomic and functional characterizations of phosphodiesterase subtype 4D in human cancers.
Academic Article Vitamin D receptor gene polymorphisms and prognosis of breast cancer among African-American and Hispanic women.
Academic Article Increased chemopreventive effect by combining arctigenin, green tea polyphenol and curcumin in prostate and breast cancer cells.
Academic Article Arctigenin in combination with quercetin synergistically enhances the antiproliferative effect in prostate cancer cells.
Academic Article Slug contributes to cancer progression by direct regulation of ERa signaling pathway.
Academic Article Sensitization to docetaxel in prostate cancer cells by green tea and quercetin.
Academic Article Activation of Akt1 accelerates carcinogen-induced tumorigenesis in mammary gland of virgin and post-lactating transgenic mice.
Academic Article Understanding Perceived Benefit of Early Cancer Detection: Community-Partnered Research with African American Women in South Los Angeles.
Academic Article Long-term exposure of MCF-12A normal human breast epithelial cells to ethanol induces epithelial mesenchymal transition and oncogenic features.
Academic Article Green tea and quercetin sensitize PC-3 xenograft prostate tumors to docetaxel chemotherapy.
Academic Article Association of Vitamin D3 Level with Breast Cancer Risk and Prognosis in African-American and Hispanic Women.
Academic Article Receptors for Insulin-Like Growth Factor-2 and Androgens as Therapeutic Targets in Triple-Negative Breast Cancer.
Academic Article Long-term exposure of MCF-7 breast cancer cells to ethanol stimulates oncogenic features.
Academic Article Aberrant Phosphorylation of SMAD4 Thr277-Mediated USP9x-SMAD4 Interaction by Free Fatty Acids Promotes Breast Cancer Metastasis.
Academic Article Time to Clinical Follow-up after Abnormal Mammogram among African American and Hispanic Women.
Academic Article Diabetes-associated dysregulated cytokines and cancer.
Academic Article Optimization Of Cancer Treatment Through Overcoming Drug Resistance.
Academic Article Targeting of PP2Cd By a Small Molecule C23 Inhibits High Glucose-Induced Breast Cancer Progression In Vivo.
Academic Article Estrogen receptor-beta is a potential target for triple negative breast cancer treatment.
Academic Article Celecoxib in breast cancer prevention and therapy.
Academic Article Transcriptomic and ChIP-sequence interrogation of EGFR signaling in HER2+ breast cancer cells reveals a dynamic chromatin landscape and S100 genes as targets.
Academic Article AMP-activated protein kinase: a potential therapeutic target for triple-negative breast cancer.
Academic Article PARP Inhibitors as a Therapeutic Agent for Homologous Recombination Deficiency in Breast Cancers.
Academic Article Response of Breast Cancer Cells to PARP Inhibitors Is Independent of BRCA Status.
Academic Article Expression of MALAT1 Promotes Trastuzumab Resistance in HER2 Overexpressing Breast Cancers.
Academic Article PP2Cd inhibits p300-mediated p53 acetylation via ATM/BRCA1 pathway to impede DNA damage response in breast cancer.
Academic Article Epithelial-Mesenchymal Transition and Breast Cancer.
Academic Article Estrogen Receptor-? and the Insulin-Like Growth Factor Axis as Potential Therapeutic Targets for Triple-Negative Breast Cancer.
Academic Article Combination treatment with flavonoid morin and telomerase inhibitor MST-312 reduces cancer stem cell traits by targeting STAT3 and telomerase.
Academic Article Lactate, a Neglected Factor for Diabetes and Cancer Interaction.
Academic Article Salinomycin Abolished STAT3 and STAT1 Interactions and Reduced Telomerase Activity in Colorectal Cancer Cells.
Academic Article A83-01 inhibits TGF-?-induced upregulation of Wnt3 and epithelial to mesenchymal transition in HER2-overexpressing breast cancer cells.
Academic Article GROa overexpression drives cell migration and invasion in triple negative breast cancer cells.
Academic Article Proinflammatory Cytokines IL-6 and TNF-a Increased Telomerase Activity through NF-?B/STAT1/STAT3 Activation, and Withaferin A Inhibited the Signaling in Colorectal Cancer Cells.
Academic Article Combination of resveratrol and 5-flurouracil enhanced anti-telomerase activity and apoptosis by inhibiting STAT3 and Akt signaling pathways in human colorectal cancer cells.
Academic Article MCP-1 is overexpressed in triple-negative breast cancers and drives cancer invasiveness and metastasis.
Academic Article Utilization of NGS technologies to investigate transcriptomic and epigenomic mechanisms in trastuzumab resistance.
Academic Article A review of the effects of healthcare disparities on the experience and survival of ovarian cancer patients of different racial and ethnic backgrounds.
Academic Article A novel curcumin analog inhibits canonical and non-canonical functions of telomerase through STAT3 and NF-?B inactivation in colorectal cancer cells.
Academic Article Arctigenin inhibits prostate tumor growth in high-fat diet fed mice through dual actions on adipose tissue and tumor.
Academic Article The role of PPM1D in cancer and advances in studies of its inhibitors.
Academic Article EMP2 Is a Novel Regulator of Stemness in Breast Cancer Cells.
Academic Article Transcriptional Regulation of CCL2 by PARP1 Is a Driver for Invasiveness in Breast Cancer.
Academic Article Bovine HDL and Dual Domain HDL-Mimetic Peptides Inhibit Tumor Development in Mice.
Academic Article CCL2/CCR2 signaling in cancer pathogenesis.
Academic Article Comp34 displays potent preclinical antitumor efficacy in triple-negative breast cancer via inhibition of NUDT3-AS4, a novel oncogenic long noncoding RNA.
Academic Article Nicotine Synergizes with High-Fat Diet to Induce an Anti-Inflammatory Microenvironment to Promote Breast Tumor Growth.
Academic Article Endometriosis: A Malignant Fingerprint.
Academic Article Basal-like breast cancer with low TGF? and high TNFa pathway activity is rich in activated memory CD4 T cells and has a good prognosis.
Academic Article Wild-Type TP53 Predicts Poor Prognosis in Patients with Gastric Cancer.
Academic Article CircRAD54L2 promotes triple-negative breast cancer progression by regulating the miR-888 family/PDK1 axis.
Academic Article Squalamines in Blockade of Tumor-Associated Angiogenesis and Cancer Progression.
Academic Article Phytochemicals in Inhibition of Prostate Cancer: Evidence from Molecular Mechanisms Studies.
Academic Article Diaporine Potentiates the Anticancer Effects of Oxaliplatin and Doxorubicin on Liver Cancer Cells.
Academic Article ZBED2 expression enhances interferon signaling and predicts better survival of estrogen receptor-negative breast cancer patients.
Academic Article Tumor-Derived Exosomes in Tumor-Induced Immune Suppression.
Academic Article Roles of Protein Disulfide Isomerase in Breast Cancer.
Academic Article Elevated Baseline Serum PD-L1 Level May Predict Poor Outcomes from Breast Cancer in African-American and Hispanic Women.
Academic Article A Novel Metabolic Reprogramming Strategy for the Treatment of Diabetes-Associated Breast Cancer.
Academic Article Genetic variants in African-American and Hispanic patients with breast cancer.
Academic Article Potential Therapies Targeting the Metabolic Reprogramming of Diabetes-Associated Breast Cancer.
Academic Article Advancing Cancer Research: Insights and Innovations in Pathogenesis and Targeted Therapies.
Academic Article From Interaction to Intervention: How Mesenchymal Stem Cells Affect and Target Triple-Negative Breast Cancer.
Academic Article Correction: Dutta et al. Transcriptional Regulation of CCL2 by PARP1 Is a Driver for Invasiveness in Breast Cancer. Cancers 2020, 12, 1317.
Academic Article Optimization of tissue microarray technique for breast cancer patients: a short communication.
Academic Article Enhanced Chemoprevention of Prostate Cancer by Combining Arctigenin with Green Tea and Quercetin in Prostate-Specific Phosphatase and Tensin Homolog Knockout Mice.
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RCMI CC is supported by the National Institute on Minority Health and Health Disparities, National Institutes of Health (NIH), through Grant Number U24MD015970. The contents of this site are solely the responsibility of the authors and do not necessarily represent the official views of the NIH

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